THE EFFECT OF NASAL OBSTRUCTION ON THE NASAL AND MIDDLE EAR MUCOSA IN EXPERIMENTAL ANIMALS
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T?ie effect of nasal obstruction on the nasal and middle ear mucosa was studied on 138 albino rats with unilateral and bilateral nasal ob struction for variable periods up to 3 months. Group 1 was composed of100 rats which were subjected to unilateral nasal closure. They were divided into 5 equal subgroups and were sacrificed after variable periods so as to study the histological changes of the nasal and ear mucosa Group II was composed of 38 rats, these being subjected to bilateral nasal closure. These had died within 9 days. The nasal mucosa of the open side showed squamous metapla sia vascular congestion and ciliary destruction while in the closed side there was increased secretory activity without epithelial dam age. The ear mucosa showed no changes in the side of open nostril while mucosal oedema occured in the side of closed nostril after 2 weeks. The chages seen in the nasal mucosa of the closed side of the nose ex plain the beniftdal effect of nostril closure in atrophtc rhinitis.