THE APPLICABILITY OF BIOMARKERS FOR DIFFERENTIATION OF INVERTED PAPILLOMA WITH DIFFERENT PATHOLOGICAL DIAGNOSES
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Objectives: The present study aimed to estimation of tissue extract ep idermal growth factor receptor (EGFR) and serum squamous cell carcino ma antigen (SCCA) levels in patients with inverted papilloma (IP) in varied pathological states as a trial to determine their role in pathogenesis and/ or their applicability for differentiation between these dfferent pathologi cal changes. Patients fit Methods: The study included 6 cases with primarily diag nosed IP, 4 cases with recurrent IP and 3 cases had IP with SCC and 10 healthy volunteers to give blood samples as control group. All patients un derwent full history taking, general and local examination and CT imag ing was conducted. All cases underwent endoscopical excision and fresh ly excised IP tissues were divided into two parts; the first for histopathological examination and the second was immediately frozen on dry ice and stored in liquid nitrogen at -7CPC until processed for estima tion of tissue extract level ofEGFR. Venous blood samples were obtained prior to and after surgical resection for ELISA estimation of serum SCCA. Results: The study included 13 patients; 10 males and 3 females, with mean age of 62.46.2 years. Nasal obstructton was the main pre senting symptom followed by epistaxis and headache. Patients with re current IP gave history ofprevtous endoscopic removal since a mean du ration of 6.2+2.2 months and one patient had recurrent IP twice. Histopathotogtoal examination documented the diagnosis of benign IP in 10 cases and SCC changes in 3 IP. Mean EGFR levels estimated in tissue extract of IP wiih SCC was significantly higher compared to benign IP with significantly higher levels in recurrent IP compared to primary IP.