THE ROLE OF OXIDANT STRESS AND PROSTAGLANDIN IN MYOCARDIAL INFARCTION AND POSSIBLE RELATION SHIP
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Oxidant stress has a role in pathophysiology of many diseases. However its role in myocardial infarction is not fully clear. Also,prostaglandins have a relation to many diseases however, its relation to myocardial infarction is not fully investigated. Also, it is not known well whether prostag landins mediate the card ioprotective effect of anti-oxidant vitamins E and C. The aim of the present work was to investigate the role of oxidant stress and prostaglandin in the pathgenseis of myocardial infarction and possible relation between them /The results of the present study showed that injection of vitamin E and vitamin C ( Known anti-oxidant vitamins) reduced the myocardial infarction induced by isoprenalin injection .thus denoting that the myocardial infarction is largely due to oxidant stress. Also the results showed that injection of voltaren ( a prostaglandin synthesis inhibitor) caused an increase in myocardial infarction induced by isoprenalin signyking a prostaglandin cardioprotective action. The results showed also that injection of voltaren together with vitamin E nearly abolished the cardioprotective action of vitamin E. This,proved that the cardioprorective effect of vitamin is mediated at least partially through prostaglandin. In contrast ,injection of voltaren with vitamin C did not affect the cardiprotective action of vitamin C.This means that the card iprotective action of vitamin C is not mediated through prostaglandin.