THE ROLE OF ANTIOXIDANT VITAMINES (C & E) ON EXPERIMENTALLY INDUCED GASTRIC ULCER
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Oxygen derived free radicals were found to be one of the major mechanisms which lead to gastric ulceration . In this work the role of vitamins E & C as antioxidant agents in protection against and healing of gastric ulcers was investigated. 48 albino rats were included in this study .They were divided into a control group (6 rats) ,induction group (6 rats) ,Vit C group (18 rats) and Vit E groups (18 rats) . The control rats were injected intraperitoneally (ix)) with normal saline for 14 days in the induction group the rats were injected with hydrocortisone sodium succinate (i.p) for 14 days for induction of gastric ulceration .Vit C group were divided into 3 subgroups each one of them includes 6 rats .The Vit C subgroups were injected with Vit C Lift in a dose of 2 mg/ kgm /day for 14 days before, during and after corticosteroid injection .Vit E group were also subdivided into 3 subgroups 6 rats each , which were injected with vit E in a dose of 30 mg / 100 gm daily S.0 for 14 days before ,during and after corticosteroid injection. The results showed that corticosteroid injection for 14 days resulted in gastric ulcer formation in all the injected rats. Treatment of rats with vitamin C and E significantly reduced the ulcer formation and help the healing of the already formed ulcers. The best protective effect was obtained when rats were supplemented with vitamin C and E during the peroid of corticosteroid injection. There were no marked differences between both vitamins in protection or healing of gastric ulcer. We conclude that vitamin C and vitamin E have a signficant protective 245 Nasr A. Belacy et al.... and healing effect against corticosteroid induced gastric ulceration in rats ,most probably due to their antioxidant effects.