EFFECTS OF TESTOSTERONE REPLACEMENT ON GROWTH HORMONE AND PROLACTIN RESPONSES TO EXERCISE IN CASTRATED RATS
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Recent years have seen an increasing interest in the study of the aging male, with particular interest in that mole hormone replacement - can improve quality of life (Verrnulen. 2001) . This study was designed to investigate the effects of testosterone replacement on SH,and PR!.. exercise responses in castrated male rats. Fifty six adult male albino rats were included in this study. The rats were classified into seven groups: Group I Sham castrated. Group II Exercised sham castrated . Group III Castrated. Group IV ExerciSed castrated . Group V Exercised castrated testosterone replacement (10 mg/ kg/ week) . Group VI Exercised castrated testosterone replacement double dose . Group VII Exercised castrated testosterone replacement half dose. After one month of . experiments all rats were sacrificed Blood samples were collected and GH and PRL levels were estimated in all animal sera. Our results showed that exercise increase both GH and PRL. in sham castrated rats. This response is abolished in castrated rats. Testosterone replacement increase both GH and PRI, response to exercise and this efl fect is dose dependent: GPI and PRL release response increase by double dose while they decrease by half dose replacement We conclude a beneficial effect of testosterone replacement in old aged men with moderate training that improve bone mass and prevents the unfavorable changes in organs upon which androgen acts through increase GH and PRL response to exercise.