Q-T. DISPERSIONINACUTEMYOCARDIAL INFARCTION : EFFECT OF THROMBOLYTIC THERAPY
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This study was performed to assess Q-T dispersion in patients with acute myocardial infarction (AMI) treated with throrhboiytic therapy ver sus conventional therapy. The study population included 50 patients: 25 were treated with streptokinase (SK) and the other 25 did not received such therapy due to contraindication. Their ages ranged between 37 to 80 years (mean 58.4 + 10.46). Thirty-six ofthem(72%) had anterior and 14 (28%) had inferior infarction. Twenty-five, age and sex-matched healthy subjects served as control group. Q-T dispersion and dispersion ratio were estimated thrice in SK-treated group (on admission, 2hrs post- Sk and predischarge), twice in non-SK treated group (on admission and predischarge) and once for controls. Statistical analysis of the results showed thatpatients on admission had highly significant increase in Q-T dispersionparameters compared to controls (p < 0.001). Subgroup analy sis showed highly significant increase in Q-T dispersion parameters in patients who were complicated compared to those who were not compli cated with complex ventricular arrhythmias during hospital course (p <0.01). Also there was highly signficant increase in theseparameters in diabetic compared to nondiabetic patients (p < 0.01). Patients who were treated with SKshowed highly signfficant decrease in dispersionparame ters 2 hours after SK infusion and on dischargeform hospital compared to that on admission (p < 0.01).