ERYTHROCYTE GLUTATHIONE PEROXIDASE AND SERUM SELENIUM IN SYSTEMIC LUPUS ERYTHEMATOSUS
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The erythrocyte glutathione peroxidase (GP) level and the concentration of serum selenium were assessed in 20 patients with active systemic lupus erythematosus and their correlation with the disease activity were studied. 12 heathy persons, matched for age and sex were taken as a control group. AU cases were subjected to clinical assessment and laboratory investigations. There was a significant decrease of erythrocyte peroxidase level and serum selenium level in patients with systemic lupus erythematosus as compared to the controls. Erythrocyte glutathione peroxid nse and serum selenium, showed a negative significant correlation with systemic lupus erythematosus activity index score (SLEDAI). From the previous results we concluded that, the decreased GP activity leads to the lack of antioxidative capacity of the glutathione peroxidase/ reductase system and this could have a pathogenic role in the pathogenesis of systemic lupus erythematosus and antioxidants can be used as markers to predict prognosis in patients with systemic lupus erythematosus.