Adipocytes are producing a variety of molecules that are capable of
functioning in both a paracrine and autocrine fashion, tumor necrosis factor
alpha is one of these molecules that has been shown to be elevated in
obese and diabetic patients a finding which was correlated to insulin resistance,
lipid abnormalities and certain types of obesity. Patients and
Methods: the present study was conducted on 46 persons ; 26 diabetics,
10 obese non diabetic and 10 non obese non diabetic persons. All of them
were subjected to the following investigations: weight, height, BMI, W/ H
ratio, fat%, lipid profile. HBAI c and TNFa determination. Results: It was
found that there is a significant elevation of (LDL, TG, cholesterol. VLDL,
• fasting blood glucose, HBA lc and TNFa) in diabetic group as compared to
control non obese group. The same situation applies to the difference between
diabetic group and obese non-diabetic group when comparing (7'G.
cholesterol, VLDL, fasting blood glucose. HBA lc and TNFa). Comparing
obese and non obese normal persons, it was found TNFa was insignificantly
elevated. Correlating TNFa with different other parameters showed
the following findings; in group 1 there was a positive correlation with
BMI and fat% while there was no significant correlation with W/ H ratio,
in groups 2 and 3 there was no significant correlation between TlVFa and
any of the different parameters, interestingly, making this correlation in
the whole sample (26 diabetic patients, 10 non obese normal persons and
10 obese non diabetic persons) it was found that TlVFa is significantly
correlated to Will ratio. LDL, cholesterol, VLDL. fasting blood glucose and
HBAlc. Conclusion: our results show that TNFa is significantly elevated
in diabetic group more than other group and is related to fat% and
BMI, this confirms the results of the previous studies and stresses its |
