STUDYOFANTIBODIES TOB2-GLYCOPROTEIN I, PROTEINCANDPROTEINSASMARKERSOF ARTERIALANDVENOUS THROMBOSIS IN PATIENTSWITHSYSTEMIC LUPUS ERYTHEMATOSUS
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In order to clarify the association between antibodies to phospholipidbinding plasmaprotein particularly; BZ-glycoprotein I, protein C and pro tein S and fhrombotic complications in systemic lupus erythematosus pa tients (SLE), 42 patients with SLE were selected and 10 healthy subjects were also included as acontrolgroup, their age and sexmatched with ourpatients. The Anti phospholipid antibodies (APLAbsj were measured by an Enzyme Linked Immunosorbant Assay (EIJSA) system. The thrombotic eventswere determined by venography, Adenography, Dopier ultra sound, computed tomography (CD and magnetic resonant image (MIR). Our result showed that all types oflgGAPLAbs were detected in SLEpa tients (30%for anti-B2-Glycoprotein I, 21%for anti-protein C and 28%for anti-protein S). thrombotic events were detected in 12 ofSLE patients (7 arterial and 5 venous). The prevalence ofLA and aCLwere significantly higher in SLE patients with thrombosis than in those without thrombosis (P < 0.01), but there was nan significant change between the prevalence ofLA and aCL in patients with arterial and venous thrombosis (P > 0.05). Concentration and prevalence of anti-B2-GPI was significantly higher in patients with arterial thrombosis than in thosewith venous thrombosis (P < 0.01). The concentration and prevalence of anti-protein C and antiprotein S Abs were significantly higher in patients with venous thrombo sis than in those with arterial thrombosis (P < 0.01).