Humoral immune response against schistosomiasis mansoni in SWAP vaccinated , infected mice
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The host protection either completely or partially is the main goal of host vaccination against infection. . This Study reports that the peak of humoral immune response is achieved 7 weeks post —vaccination among SWAP(Soluble Worm Antigen Preparation) vaccinated mice, then declines. There are insignificant variations of humoral immune response ( Anti — SWAP IgE ,IgM and IgG ) among SWAP vaccinated , challenged mice and among control infected mice, but antibody / antigen ratio is significantly higher ( Z value > 1.96 ) among SWAP vaccinated , challenged mice than that among control infected mice when antibody induced in a ratio with the count of worm burden ( 38.6 ±5.5 _),( 74.2 ±9.9) respectively. Praziquantel ( PZQ) therapy , often temporarly, increases the humoral immune response 4 weeks after treatment. SWAP vaccination significantly decreases worm burden 48% (protection percentage ) among SWAP vaecinated challenged mice than that in control infected mice which indicates on partial protection against schistosomiasis. This result represent the role of humoral response as one factor for induction of partial protection (acquired resistance ) and further studies are needed for the other factors which are responsible and sharing in the acquired resistance against schistosomiasis.