Acute effect of sildenafil on myocardial ischemic territories in patients with stable coronary artery disease
|Full paper||Not Available|
To test the safety of sildenafil in patients with stable coronary artery disease Sildenafil; : • •(CAD). Coronary artery disease; • ^Methods: Sixty-one patients with stable CAD, documented by coronary angiography were Stable angina . ::included in this phase 1 study. Patients were randomized to either single dose sildenafil ormatched : '•'•:.- '[^placebo. Speckle tracking echocardiography was done at baseline and 60 min after sildenafil/pla- .•';' ; 'f ^cebo intake to calculate peak systolic strain (PSS) of themost severely affectedmyocardial segments : ' :.•;;::and the global longitudinal PSS.