To test the safety of sildenafil in patients with stable coronary artery disease
Sildenafil; : • •(CAD).
Coronary artery disease; • ^Methods: Sixty-one patients with stable CAD, documented by coronary angiography were
Stable angina . ::included in this phase 1 study. Patients were randomized to either single dose sildenafil ormatched
: '•'•:.- '[^placebo. Speckle tracking echocardiography was done at baseline and 60 min after sildenafil/pla-
.•';' ; 'f ^cebo intake to calculate peak systolic strain (PSS) of themost severely affectedmyocardial segments
: ' :.•;;::and the global longitudinal PSS. |
