Praziquarttel (PZQ) efficacy is known to depend in part on the host immune
response to infection. The study of schistosomal cases that resist or
tolerate PZQ therapy after multiple doses includes the host immune system,
the drug and the schistosomes characters
In the present work, a trial to assess serum trace elements (Zinc 81,
Copper) by Atomic absorption spectrometry and to evaluate hwnoral immtme
response of susceptible (cured) and resistant (non-cured) schistosomal
cases for PZQ therapy by ELISA to measure antischistosomal antibodies
(Anti-SWAP IgG & IgM) of schistosomal cases in a rural area of
Nile Delta of Egypt.
There are insigncant variations of serum trace elements (Zinc & Copper)
levels between 4 different groups of schistosomal cases that received
single, double (40 mg/ kg) and triple doses (60 mg/ kg b.w.) of PZQ, while
serum Copper among schistosomal cases are significantly higher than
healthy control cases. These results may denote that PZQ cannot affect
trace elements levels among different groups of schistosomal cases. Moreover,
no significant variations in the level of the schistosomal antibodies
(Anti-SWAP IgG & IgM) among different groups of schistosomal cases
which may indicate on the integrity of immune response of infected cases
either susceptible or resistant cases for PZQ therapy |
