ALTERATION IN BRAIN REGIONAL MONAMINE LEVELS AFTER CHRONIC ADMINISTRATION OF VALPROIC ACID IN RAT BRAIN
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Sodium Valproate ( S.V.) is a well established anticonvulsant drug. The aim of the present work was to study the effect of S.V. ( 200 mg / kg B. W. LP.) once dose / day for 45 days, on some neurotransmitters Norepinephrin (NE) , Dopamine ( DA) and Serotonirte (SPIT) in differentareas of rat brain (cerebral cortex, thalamus-hypothalamus, midbrain and hindbrain) to evaluate its possible anticonvulsant effect, and to explain some of its unwanted effects. Results of the present work showed that S.V. is responsible for significant elevation of NE level (Pc 0.05) in thalamus-hypothalamus and midbrain. and significant elevation of DA level (P< 0.05) in cerebral cortex and thalamus-hypothalamus. 5HT levl was significantly elevated (P<0.05) in thalamus-hypothalamus , cerebral cortex and midbrain . In conclusion: the present findings suggest that the anticonvulsant effect of S.V. might be due to modulation of monoarninergic system differentially in difierent brain areas Moreover, in thalamus-hypothalamus . increased NE and increased DA levels may explain appetite stimulant effect and weight gain induced by S.V. therapy, and increased SLIT level in cerebral cortex may explain its sedative effect.