Sodium Valproate ( S.V.) is a well established anticonvulsant drug.
The aim of the present work was to study the effect of S.V. ( 200 mg / kg
B. W. LP.) once dose / day for 45 days, on some neurotransmitters Norepinephrin
(NE) , Dopamine ( DA) and Serotonirte (SPIT) in differentareas
of rat brain (cerebral cortex, thalamus-hypothalamus, midbrain and hindbrain)
to evaluate its possible anticonvulsant effect, and to explain some
of its unwanted effects.
Results of the present work showed that S.V. is responsible for significant
elevation of NE level (Pc 0.05) in thalamus-hypothalamus and midbrain.
and significant elevation of DA level (P< 0.05) in cerebral cortex
and thalamus-hypothalamus. 5HT levl was significantly elevated
(P<0.05) in thalamus-hypothalamus , cerebral cortex and midbrain .
In conclusion: the present findings suggest that the anticonvulsant effect
of S.V. might be due to modulation of monoarninergic system differentially
in difierent brain areas Moreover, in thalamus-hypothalamus . increased
NE and increased DA levels may explain appetite stimulant effect
and weight gain induced by S.V. therapy, and increased SLIT level in cerebral
cortex may explain its sedative effect. |
