ANALGESIC EFFECT OF TIANEPTINE IN EXPERIMENTALLY INDUCED HYPERALGESIA IN RATS
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The effect of Tianeptine (Img/ kg 13.W. LP.) on cortical acetylcholine and serotonine in experimentally induced hyperalgesia in rats by 1% Carrageenin (25 ul, Lpl.) was made to evaluate the possible analgesic effect of Tianeptine. Results of the present work revealed that hyperalgesia resulted in significant elevation of cortical acetylcholine and reduction of cortical serotonine levels. Moreover. Tianeptine (1mg /kg B.W. I.P.) pretreated hyperalgesic rats resulted in significant elevation of both acetylcholine and serotonine levels in rat s cerebral cortex which may account its analgesic effect.