A COMPARATIVE STUDY OF SOME . PHARMACOLOGICAL EFFECTS OF TIANEPTINE VERSUS AMITRIPTYLINE
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The present study was carried out to screen the anticholinergic and cardiovascular side effects of tianeptine and to evaluate its analgesic effects versus amitriptyline. Data obtained in the present work pointed out those gradually increasing doses of tianeptine induced non-significant inhibition of rhythmic contractions of rabbit jejunum (P > 0.05). While, gradually increasing doses of amitriptylene, however, induced a significant inhibition of rhythmic contractions of isolated rabbit jejunum (P < 0.05). Tianeptine had less inhibitory effect on isolated rabbit intestine than amitriptyline when added in the same concentrations. Moreover, the inhibitory effect of tianeptine and amitriptyline were not affected by prior addition of alpha- and beta-adrenoreceptor blockers (phentolamine and propranolol, respectively) or the dopaminergic receptor blocker (metoclopramide). In addition, tianeptine produced a non-significant decrease in acetylcholine (A Ch) induced intestinal contractions, while, amitriptyline significantly attenuated A Ch- induced contractions of isolated rabbit intestine. Regarding the effect on cardiovascular system, the results of the present work showed that, gradually increasing concentrations of both tianeptine and amitraptyline produced a non- significant decrease in the 'contractility of isolated rabbit bean (P >0.05). Gradually increasing concentrations of tianeptine produced a non- significant decrease in norepinephrine-induced contraction of isolated rabbit aortic strip while amitriptyline in a concentration of 32 ug/ml produced significant decrease in norepinephrine- induced contraction of isolated rabbit aortic strip. The results of the present work showed that, acute administration of tianeptine and amitriptyline produced a nonsignificant decrease in mean systolic blood pressure and in the bean rate of anaesthetized rats. Moreover, acute administration of tianeptine and amitriptyline had a significant analgesic effect (11/40.05) with no differences between the analgesic potency of both drugs. In conclusion, tianeptine had low incidence of anticholinergic effects, postural hypotension and cardiotoxicity in comparison with amitriptyline, which had moderate to marked anticholinergic side effects. In addition, it produced an analgesic effect which can be useful in depressed patients.