Adenosine has been demonstrated to have an anticonvulsant action
which is mediated by adenosine Alreceptor subtype. diphenylhydantoin
(DPH) is probably the most useful drug in treating most forms of epilepsy in
spite of its many side effects. So, the possible combining of the two drugs
may have a quantitative synergism or a better efficacy versus toxicity ratio.
An animal model of epilepsy was induced by the administration of
pentylenetetrazole (PTZ) (85 mg/kg S.C.). Adenosine was injected
intraperitoneal (I.P.) while (DPH) was injected subcutaneously (S.C.) in the
back of the neck The acute anticonvulsant effect of adenosine and DPH was
studied during a period of 60 minutes. The motor coordination (time in
seconds) using the Rotord test was also estimated.
Administration of adenosine produces a significant reduction of
duration of seizures as well as DPH, and they induce less motor
incoordination. |
