The Effect of Adenosine in Epilepsy induced experimentally in rats
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Adenosine has been demonstrated to have an anticonvulsant action which is mediated by adenosine Alreceptor subtype. diphenylhydantoin (DPH) is probably the most useful drug in treating most forms of epilepsy in spite of its many side effects. So, the possible combining of the two drugs may have a quantitative synergism or a better efficacy versus toxicity ratio. An animal model of epilepsy was induced by the administration of pentylenetetrazole (PTZ) (85 mg/kg S.C.). Adenosine was injected intraperitoneal (I.P.) while (DPH) was injected subcutaneously (S.C.) in the back of the neck The acute anticonvulsant effect of adenosine and DPH was studied during a period of 60 minutes. The motor coordination (time in seconds) using the Rotord test was also estimated. Administration of adenosine produces a significant reduction of duration of seizures as well as DPH, and they induce less motor incoordination.