Comparison effects of enalapril and candesartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet
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The effects of the angiotensin converting enzyme (ACE) inhibitor enalapril were compared with the angiotensin ATI receptor antagonist candes:, - in in cyclosporine A (CsA)-induced hypertension and nephrotoxicity in spontaneously hypertensive rats (SHR). SHR (8-9 weeks old) on high-sodium diet were given CsA (5 mg/kg/d s.c.) for 6 weeks. The rats were treated concomitantly either with enalapril (30 mg/kg/d p.o.) or candesartan (4 or 32 mg/kg/d p.o.). Blood pressure was recorded every second week by tail cuff method. Renal function was measured by serum creatinine, creatinine clearance and urinary excretion of proteins at the end of the experiment. CsA caused hypertension, impaired renal function and induced morphological nephrotoxicity with glomerular damage and interstitial fibrosis. Enalapril and the lower dose of candesartan attenuated the CsAinduced hypertension to the same extent, while the higher dose of candesartan totally abolished it. Enalapril and candesartan equally prevented the CsA-induced deterioration of kidney function and morphology.