Publications of Faculty of Medicine:Effect of candesartan cilextel in Freund's adjuvant-induced arthritis in albino rats: Abstract

Effect of candesartan cilextel in Freund's adjuvant-induced arthritis in albino rats
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The renin-angiotensin system plays an important role in the regulation of cardiovascular, renal, and endocrine functions. Local functional renin-angiotensin systems (RAS) have been demonstrated in many organ and tissue systems. It was found that the angiotensin II receptor blockers (ARBs) suppressed the development of severe arthritis and joint destruction in the collagen-induced arthritis model. These findings suggest that ARBs may have therapeutic potential in rheumatoid arthritis. All animals (30 male rats) were subjected to measurements of the hind paw thickness and pressure threshold by using analgesymeter. Subsequently, Freund's adjuvant was injected into the base of rat-tail. Sixteen days after administration of Freund's adjuvant, animals were again subjected to the previously mentioned tests and were randomly assigned to 3 groups: I) Control group (II) candesartan cilextil Treated group (III) celecoxib treated group All animals were subjected to the previous tests at days 15,30 after starting treatment, then all animals were scarified, following scarification, the stomachs were removed. Gastric contents were collected for evaluation of biochemical parameters. The stomachs were opened along the greater curvature and the gastric lesions were evaluated for identifying the ulcer index. In this work candesartan cilextil and celecoxib showed significant beneficial effect (anti-inflammatory and analgesic) compared to arthritic control non-treated group.