ROLE OF PENTOXIFYLLINE IN ACUTE PANCREATITIS
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Involvement of reactive oxygen radicals, nitric oxide and cytokines has been implicated in the initiation of pancreatic tissue damage and impairment of the pancreatic microcirculation in acute pancreatitis. Pentoxifylline is a methylxanthine derivative with marked anti- inflammatory properties in addition to its inhibition for the pro-inflammatory cytokines production. Our aim is to examine whether pentoxifylline ameliorates inflammatory infiltrate and glutathione depletion associated with cerulein-induced pancreatitis. Cotreatment of animals with pentoxifylline prevented both mitochondrial swelling and damage to mitochondrial cristae caused by cerulein. reduced cerulin-induced pancreatic inflammation and significantly (P <0.05) reduced the increase in lipohydroperoxides (LP0). nitrate levels and the depletion of pancreatic glutathione. Our results provide a possibility of using pentoxif).711ine to attenuate the inflammation within the pancreas and as an adjuvant in the treatment of acute pancreatitis.