This work was performed to study the effects of two drugs (cefepime
and levofinracin on the liver and kidney functions of normal albino
rats, moreover, a histopathological examination of kidney and liver was
done. In this study, fourty five male albino rats (120-180 gm each)
were divided into three groups 15 rats served as control, 15 rats treated
daily with cefepime (0.5 mg/rat) intraperitoneally (IP), 15 rats treated
daily with levofloxacin (0.25 mg/rat) intraperitoneally UP). After 14
days from drugs administration. 10 rats from each group were used for
examination. Blood samples were collected from the retrobulbar plexus
and analysed for determination of total serum bilirubin, serum
aspartate amino transferase (AST), serum alanine amino transferase
(ALT), serum alkaline phosphatase (ALfl serum urea and creatinine.
After obtaining the blood samples, the animals were sacrificed and
their livers and kidneys were removed and examined by electronmicroscope
for any histopathological changes. Five rats from each treated
group were left without treatment for 7 days, then all the above investigations
were carried out again. The results of this study as regards
the liver functions showed that there was a significant increase in. AST,
ALT and ALP in both cefepime and levollaxacin treated groups. The increase
induced by levoflaxacin was more. There was insignificant
change in the serum bilirubin in both treated groups as compared with
control group. Concerning the renal functions, there was a significant inerectee
in serum urea and creatinine in levolloxacin treated group but
this increase was insignificant in cefepime treated group. The changes
observed in the parameters measured were found to be transient and reversible
as evidenced by return of the values to the control level after
stoppage of treatment Histopathola3ical results of liver and kidney
showed no significant change which correlate with the reversibility of biochemical
results. Therefore, it could be concluded that therapy with the
above two drugs must be controlled by regular assessment of the liver
and renal functions tests even in asymptomatic patients. |
