COMPARATIVE CLINICAL TRIAL OF SODIUM VALPROATE AND CARBAMAZEPINE IN EGYPTIAN PATIENTS WITH EPILEPSY
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This study was canied out on 40 egyptian epileptic patients, 20 on valproate (30 - 50 mg/kg oral/day) and 20 patients were on carbamazepine (20 - 40 mg/kg/oral/day). Results of the present work demonstrated that some adverse effects higher in valproate monotherapy than carbamazepine monotherapy as tremors (10%), weight gain (20%) and appetite gain (10%), but others were higher in carbamazepine monotherapy than valproate monotherapy like headache (10%), rash (10%) and gastrointestinal troubles (15%). Moreover some side effects occured with Carbamazepine monotherapy like decreased lipido (5%) but not with valproate. Also, there were no significant hematological changes either with valproate or carbamazepine, Moreover, SGOT, SGPT and total bilirubin were significantly elevated (p < 0.05) in valproate not with carbamazepine monotherapy. Finally, this study sufficiently provide useful informations of adverse events when treating adult patients with monotherapy with valproate or carbamazepine in a neurological out patient clinic in Benha University Hospital.