IMMUNOLOGICAL EFFECTS OF NUN VACCINE, A CHEMICALLY MOD IF BIOMPHALARIA ALEXANDRINA SNAIL ANTIGEN
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The development of a vaccine that brings schistosomiasis under immunological control has been the goal of many investigators all over the world for decades. This study was designed to test the effects of NHN vaccine which contains chemically modified Biomphalaria alexandrina snail antigen on reducing the worm burden, stimulating body immune response and on the incidence of pathological changes in different organs, testing its prophylactic and its curative effects. Statistical analysis of the results showed that NBN dose-dependantly raised the IgG titre in the vaccinated mice. The number of worms recovered from mice pre-injected with the vaccine then infected with schistosomal cercariae (15 ouse) was about 10% of the number recovered from mice infected non-vaccinated. Vaccination with NHN significantly reduced the incidence of pathological changes in livers and intestines in infected mice. These results suggest a possible potent effect of the compound tested (NHN vaccine) in preventing and even curing the pathological consequences of schistosomiasis infection.