EFFECT OF AMINEFTINE (A NEW TRICYCLIC ANTIDEPRESSANT) VERSUS AMITRIPTYLINE ON THE LEVER OF ALBINO RATS
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Thirty mature albino rats were divided into three equal groups. Amitriptyline (4.5 mg/kg), amineptine (9 mg/kg) and distilled water were given orally and daily for a period of 12 weeks to rats of the first, second and third groups respectively. Histopathological examination of rat's livers revealed pictures of cholestatic hepatitis in amitriptyline group and microvesicular steatosis in amineptine group. Values of biochemical parameters (total bilirubin, alkaline phosphatase and ALT & AST enzymes) were all significantly elevated with amineptine. With amitriptyline, only total bilirubin and alkaline phosphatase values were significantly elevated while the increase in ALT and AST values were not significant.