A THERAPEUTIC POTENTIAL EFFECT OF NICOTINAMIDE IN DIABETES PREVENTION
|Full paper||Not Available|
The protective effect of nicotinamide (NA) on type II diabetes mellitus induced in rats by streptozotocin (STZ) (50 mg/kg I.P. single dose) was assessed . The degree of protection was determined biochemically by measuring pancreatic nitric oxide (NO) and fasting blood glucose level(FBG) and by histopathological examination of beta cells (f3-cells). In addition, the study also extended to detect the effect of NA on liver 8c kidney functions. In STZ induced diabetic rats, there were significant elevation (P005) of pancreatic NO2 and NO3 and FBG levels, as well as reduction in number size, fibrosis and hydropic degeneration of 13-cells. In rats pretreated with NA (1% in drinking water 3 weeks before diabetes induction), pancreatic nitrite (NO2 ) and nitrate (NO3 ) levels were significantly (1=1 0.05) reduced in addition to more or less normal histopathological picture of 13-cells, but alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly elevated (PD3.05). Moreover, in NA post-treated diabetic rats, pancreatic. NO2 and NO3 and fasting blood glucose (FBG) levels were non significantly changed (13?,.0.05) compared with diabetic non-treated rates with persistant of the same histopathological picture of 13-cells. In conclusion, these findings support the suitability of NA for trials designed to delay or prevent the onset of diabetes mellitus .