EFFECT OF SOME NATURAL PLANT AND ANIMAL COMPOUNDS VERSUS BEZAFIBRATE ON EXPERI - MENTAL MODEL OF ATHEROSCLEROSIS IN RATS
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The present work aimed to clarify and investigate the beneficial or toxic effects of some commonly used natural compounds; Royal Jelly, Nigella sativum ( Baraka oil ) , Allium sativum ( garlic oil) and Omega - 3 fatty acids . Their effects on long - term administration in male albino rats fed high cholestrol diet for two months were studied. The effects investigated were their actions on blood lipid profile ; total cholesterol (TC ), triglycerids (TG) , high density lipoproteins (HDL)and low density lipoproteins ( L D L) as well as their histopathological effecti on blood vessels versus the com-monly used antiatherosclerotic drug; bezafibrate . Also their effects on some biochemical parameters ; liver function tests ( as serum albumin, serum bilirubin , A L P, SGOT and SGPT ) and kidney function tests ( as serum creatinine and urea) were investigated. The effects of these compounds on the immune system were also investigated by measuring the T- lymphocyte and IgG titres. Animals were divided into 7 groups ( each was 10 rats) ; normal group ( fed only standard diet for 2 months ) , atherosclerotic group ( fed high cholesterol, 100 mg/kg / day p .,o) for two months , other five groups fed high cholesterol diet for 2 months and oral Royal jelly ( R . J) ,Nigella sativum ( N. S ) , Omega- 3 fatty acids, garline and bezafibrate respectively. From the results of this study it can be concluded that all compounds used had a significant protective effect on the lipid profile and blood vessels and can be used in prevention of progression and development of atherosclerosis . It was found also that these compounds have a beneficial effect on the immunity system as they have an immunostimulant effect except Omega 3 - fatty acids ( which have an inununosuppressant effect) on long term administration.