Publications of Faculty of Medicine:Circulating Intercelluar Adhesion Molecules - 1 In Some Glomerular Disorders : Abstract

Circulating Intercelluar Adhesion Molecules - 1 In Some Glomerular Disorders
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Intercellular adhesion molecule-I (ICAM-1) is regulated by pro-inflammatory cytokines and plays an important role in immune response in various disease states . In this study the serum levels of circulating ICAM-1 (cICAM-1) were measured in 90 children; 20 of them had nephrotic syndrome before treatment, 20 with nephrotic syndrome during remission, 20 nephrotic patients in replase, 20 with post-streptococcal glomerulonephritis and 10 were healthy controls. We have found that the mean scrum level of cICAM-I was significantly higher in nephrotic syndrome before treatment than in healthy Controls (P<0.01), whereas it was significantly lower during remission than controls (P<0.01), but in relapse there was no significant difference when compared with the healthy controls. Also we have found that, there was no significant difference between post-streptococcal glomerulonephritis and healthy controls as regards cICAM-1. We concluded that the serum levels of cICAM-1 were significantly elevated in nephrotic syndyome before treatment and significantly decreased during remission but had no significant difference in relapse as well as in post-streptococcal glomerulonephritis compared to that of healthy controls