Intercellular adhesion molecule-I (ICAM-1) is regulated by pro-inflammatory
cytokines and plays an important role in immune response in various disease states .
In this study the serum levels of circulating ICAM-1 (cICAM-1) were measured in
90 children; 20 of them had nephrotic syndrome before treatment, 20 with nephrotic
syndrome during remission, 20 nephrotic patients in replase, 20 with
post-streptococcal glomerulonephritis and 10 were healthy controls. We have found
that the mean scrum level of cICAM-I was significantly higher in nephrotic
syndrome before treatment than in healthy Controls (P<0.01), whereas it was
significantly lower during remission than controls (P<0.01), but in relapse there was
no significant difference when compared with the healthy controls. Also we have
found that, there was no significant difference between post-streptococcal
glomerulonephritis and healthy controls as regards cICAM-1. We concluded that the
serum levels of cICAM-1 were significantly elevated in nephrotic syndyome before
treatment and significantly decreased during remission but had no significant
difference in relapse as well as in post-streptococcal glomerulonephritis compared to
that of healthy controls |
