Publications of Faculty of Medicine:Attenuation of Cardiopulmonary Bypass — Induced Inflammatory Response By Dexamethasone : Abstract

Attenuation of Cardiopulmonary Bypass — Induced Inflammatory Response By Dexamethasone
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The present study examined the effect of CPB on the release of TNF-a as a pro- inflammatory cytokine and IL-10 as an antiinflammatory cytolcine and defined the effect of pretreatment with dexamethasone din the release of both cytolcines. The study included 20 patients undergoing valve replacement surgery, including 10 control patients and 10 patients who received dexamethasone 1 mg. Kg' 4 hours before surgery and 0.5 mg. kg' 6 hours later. Cytokines were measured by ELISA technique before treatment, one hour after aortic clamp application, on hour after declamping and 24 hours postoperatively. In the control group TNF- a level increased in all samples and reached its maximal level one hour after reperfusion. TNF -a also rose in the dexamethasone group but the elevation was less than the control group IL 10 levels rose moderately in the control group especially one hour after aortic declamping. Moreover administration of dexanethasone increased IL-10 levels more than the control group. In Conclusion The present study indiactes that CPB is a ccompained by release of both pro- and anti inflammatory cytolcines (TNF-a AND IL-10) and corticosteraids enhance the release of IL-10.furthermor stimulation of anti- inflammatory response is accompained by improvement of P(A-a)02