Serum Neopterin Levels In Patients With Coronary Artery Disease and it's correlation To Some Risk Factors
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This study was designed to detect the different relations between the serum neopterin levels and some risk factors (smoking, hypercholesterol-aernia,diabetes and hypertension)in patients with coronary artery diseases(CAD). It included 65 individuals classified as follows: 23 patient with acute coronary syndrome(ACS); i 6 male (69.6%) and 7 female (30.4%), 20 patient with stable angina (SA);15 male - (75.0%) and 5 female (25%) and 22 control subjects; 15 male (68.2%) and 7 females (31.8%). The age of the studied groups ranged 41-54 years. Serum samples were collected from patients Iv, ithin 24 hours of admission to coronary care unit(CCU): and healthy controls Senim neopterin level was determined by the enzyme linked immunosorbent assay(ELISA) Mean serum neopterin levels in ACS group was(18.8±3.3nmol/L) and in the SA group was (16.3+2.4 nmol/L), both were significantly higher than that in controls(8.2±2.5nmol/L) (p<0.001)and its level in ACS was statistically significantly higher than that in SA groups (p=0.007). There were non significant statistical values in the correlations of the sex and age with the neopterin levels in the patients groups. The mean neopterin level in smokers of SA group(16.2±2 7nmol/L) was lower than that in smokers of ACS group(17.8±2 7nmol/L). it was higher in non smokers than the smokers of ACS group and there were no difference in the mean neopterin levels in the smokers and non smokers of SA group. M+SD of neopterin level in patients with hypercholesterolaemia in SA aroup(16.33±2.46nmol/L)was lower than that in ACS group (18.0±3.85nmol/L) and there are non significant statistical correlations between the mean neopterin and cholesterol levels in ACS and SA groups (p=0.1 5,p=0.9 respectively). Diabetic patients had higher neopterin levels than non diabetics in ACS and SA groups.There are significant and non significant statistical correlations between the mean neopterin level and diabetes in ACS and SA patients(p=0.006,p=0.87 respectively). In ACS group the mean neopterin level in hypertensive was lower than that in normotensive patients, while in SA group there were no difference in the mean neopterin level between hypertensive and normotensive patients and there are non significant statistical correlations between the neopterin level and blood pressure in ACS and SA groups.