Study of Serum Adiponeetin level in Obese and Non-obese Asthmatic Patients
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Background : Asthma is a worldwide problem, with an estimated 300 million affected individuals. Although central (visceral) adipocytes are the most important source of adiponectin (APN), there is a tendency for reduced serum adiponectin concentration among obese subjects suggesting that decreased APN levels may contribute to the increased inflammatory state as in asthma. Aim of the work: The aim of this work was to determine whether serum concentration of adiponectin changed in asthmatic patients during acute attack and in remission or not. Subjects and Methods: Fifty five subjects were included in this study from Chest department, Bertha university hospital .40 patients with bronchial astluna(20 obese and 20 nonobese) and 15 age related healthy subject(7 obese and 8 nonobese) as a control. All asthmatic patients and control group were divided into non-obese and obese according to their body mass index(BMI) Those with BMI c25& >18.5 were considered non-obese, Those with BMI> 30 were considered obese .Those with BMI . 25 and. 30 were considered overweight and were not included in this study (NIH/NHLBI, 1998). All subjects were submitted to the following, Full history taking ,Complete physical examination(General & Local),Plain x-ray chest P-A & left lateral views ,Complete blood count, Erythrocyte sedimentation rate, Liver and kidney function tests, Fasting and post prandial blood sugar, Ventilatory function tests , Venous blood samples were taken for Adiponectin level measurement.