SENSITIVITY AND SPECIFICITY OFMYOGLOBIN IN EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
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This work was carried out on 24 patients suffering fromacute chest pain suspicious of acutemyocardial infarction (AMI) and 10 well matched normal controls. Patients and controls had undergone electro-cardiographicmonitoring (ECG), determination of serumcreatine phosphokinase (CPK) and serummyogiobin by turbidimetric immunoassay. Out of these 24 patients 9 proved to have unstable angina and 15 had AMI. Eleven patients were admitted within 24 hours and 13 within 6 hours fromthe onset of chest pain. Out of these 13 patients only 9 had AMI . Sensitivity ofmyogiobin , CPK and ECG in all patientswithAMI was 86.8% , 60% and 66.6% respectively. The sensitivity ofmyogiobin and CPKinAMIpatients admitted with in 6 hours was 88.8% and 33.33% , respectively . The specificity formyogiobin , CPK and ECG in all AMI patientswas 100%. There fore serum mygolobin assay by immunoturbidmetric method can be considered as a sensitive and specific test to diagnose AMI in the first few hours and also to identify those patients without definite ECG changes.