Publications of Faculty of Medicine:SCHISTOSOIVIAL PATHOLuGICAL CHANGES IN MICE VACCINATED WITH SWAP, CHALLENGED AND TREATED WITH PRAZIQUANTEL: Abstract

Title:
SCHISTOSOIVIAL PATHOLuGICAL CHANGES IN MICE VACCINATED WITH SWAP, CHALLENGED AND TREATED WITH PRAZIQUANTEL
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Abstract:

SWAP vaccinated mice and challenged with Schistosoma mansoni (100 ± 20 / mice) showed a significantly decrease in worm burden of pceerrfucasreida vaccinated mice compared with control infected mice, and also minimized the size and number of granuloma in different tissues ( intestine, spleen and liver) Praziquantel(PZQ) therapy showed a significant decrease in egg granuloma number in the intestine meanwhile the liver showed less significant decrease in egg granuloma number with diminution of granuloma size. Worm granuloma was observed in the liver after PZQ treatment attributed to worm shift to the liver These data may guide and recowmhmicehn md afoyl lobwe up and repeat therapeutic dose to kill shifted worms to the liver. markeTdh dereec rise aas sey nine rgism betvireen drug therapy and vaccination, which showed egg granuloma size and number in the liver, while the intestine was nearly cured. Finally SWAP vaccinated mice showed a partial protection due to acquired immunity where the mice are still susceptible for