ZINC, COPPER AND IMMUNOGLOBULINS LEVELS AMONG RESISTANT AND SUSCEPTIBLE SCHISTOSOIVIAL CASES TO PRAZIQUANTEL THERAPY
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Praziquarttel (PZQ) efficacy is known to depend in part on the host immune response to infection. The study of schistosomal cases that resist or tolerate PZQ therapy after multiple doses includes the host immune system, the drug and the schistosomes characters In the present work, a trial to assess serum trace elements (Zinc &. Copper) by Atomic absorption spectrometry and to evaluate humoral immune response of susceptible (cured) and resistant (non-cured) schistosomnl cases for PZQ therapy by &ISA to measure antischistosomat antibodies (Anti-SWAP IgG & IgM) of schistosomal cases in a rural area of Nile Delta of Egypt. There are insignificant variations of serum trace elements (Zinc & Copper) levels between 4 different groups of schistosomal cases that received single, double (40 mg / kg) and triple doses (60 mg/kg b.w.) of PZQ, while serum Copper among schistosomal cases are significantly higher than healthy control cases. These results may denote that PZQ rannot affect trace elements levels among different groups of schistosomnl cases. Moreover, no significant variations in the level of the schistosomal antibodies (Anti-SWAP IgG 82. IgM) among different groups of schistosomal cases which may indicate on the integrity of immune response of infected cases either susceptible or resistant cases for PZQ therapy.