Publications of Faculty of Medicine:CalciotropicHormones (1,25DihydroxyVitaminDand ParathyroidHormone) and PlasmaReninActivity in Essential Hypertension: Abstract

CalciotropicHormones (1,25DihydroxyVitaminDand ParathyroidHormone) and PlasmaReninActivity in Essential Hypertension
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Aim of this work is to study calcium homeostasis in essential hypertension through evaluation of calciotropic hormones and their relations to renin level. Thirty hyper tensive patients and ten normal volunteer persons were in cluded in this study, patients and control were subjected to full medical history and examination, complete urine ex amination, fasting blood sugar, blood urea nitrogen, complete blood picture, abdominal ultrasonography, serum creatinine, serum potassium, serum sodium, serum calcium, 24 hours urinary calcium, serum 1,25 dihydroxy vi tamin D, serum parathyroid hormone (PTH) and plasma renin activity. The results of this work showed no signifi cant differences between the mean serum calcium values in the hypertensive group and the control group, a signifi cant elevation of 24 hours urinary calciumin the hypertensive group when compared to the control group and a sig nificant elevation of the mean value of serum 1,25 (OH)2D and serumPTH in the hypertensive group when compared to the control group. No correlations were observed among serum PTH, serum 1,25 (OH)2D and urinary calcium in the hypertensive group. From this study we came to conclusion that hypercalciuria is a major derangement of cal cium metabolism in patients with essential hypertension. The elevated PTH and 1,25 (OH)2D might be a compensa tory response to restore calcium balance to normal, these calciotropic hormones directly facilitate calcium transport intracellaurly, intracellular calcium accumulation and hence increase cytosolic free Ca^+ which is crucial for vascular contractile activity and hence elevation of blood pressure.