SENSITIVITY AND SPECIFICITY OKMYOGLOBIN IN EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
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This work was carried out on 24 patients suffering fromacute chest pain suspicions of acutemyocardial infarction (AMI) and 10well matched normal controls. Patients and controls had undergone electro-cardiographicmonitoring (ECG), determination of serumcreatine phosphokinase (CPK) and serummyoglobin by tuibidimetric immunoassay. Outof tbese 24patients 9proved to haveunstable angina and 15hadAMI. Eleven patients were admitted within 24 hours and 13within 6 hours fromthe onsetof chestpain.Out of these 13 patients only 9 hadAMI . Sensitivity fmyoglobin , CPKand ECG inailpatientswith AMIwas 86.8% , 60%and 66.6%respectively . The sensitivityofmyoglobinandCPKinAMIpatients admittedwith in 6 hours was 88.8% and 33.33% , respectively . The specificity formyoglobin , CPKandECGinallAMIpatientswas 100%.There fore serummygolobin assay by mmunoturbidmetric method can be considered as a sensitive and specific test to diagnoseAMI inthe first few hours and also to identify those patients without definite ECG changes.