SERUM OSTEOCALCIN AS A MARKER OF BONE DYNAMICS IN THE ELDERLY
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This study was a trial to evaluate the potential value of scrum ostcocalcin (BGP) as a marker of bone turnover in elderly ostcoporotic male patients and to assess bone dynamics in elderly males via estimation of serum osteocalcin.* Forty-five cases all were males. (15 middle aged normal control cases, 15 elderly non-osteoporotic males and 15 males with senile osteo porosis) comprised thematerial of this study. * For each case of this study; full history, complete clinical examination laboratory investigations(included blood picture, stool and urine analysis, blood sugar estimation, renal, and liver profile) for exclusion of any underlying disease, radiologic study (X-ray spine) and estimation of scrum calcium, phosphorus, alkaline phosphatasc and serum osteocalcin, all were done. Serum osteocalcin (BGP) was measured by the radioimmunoassay technique. Serum calciumand phosphorus were normal in all subjects of this study. The study re vealed that both serum alkaline phosphatase levels and also, serum osteocalcin levels increased with age, and the increase for these two parameters was higher in the osteoporotic patients. Also, there was a significant correlation between serum alkaline phosphatase hi the elderly groups. We found that scrum oslcocalcin in the first group cases was 3.820.8 ng/ml and in the second group was 7.131.7 ml while it was 13.403.9 ng/ml inthe osteoporotic group.We may conclude that serial measurements of ser um ostcocalcin in elderly individuals may be helpful in study of their bone dynamics and early diagnosis of senile osteoporosis.