THE EFFECT OF HYPERGLYCEMIA ON SERUM TRANSFORMING GROWTH FACTOR-B1 (TGF-B1) LEVEL AND THEIR RELATIONS TO DIABETIC NEPHROPATHY IN PATIENTS WITH CONTROLLED TYPE 2 DIABETES MELLITUS
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TGF-131 plays a critical role in the pathogenesis of different opes of nephropathy. The current work aimed at investigating the effects of hyperglycemia on serum TGF-,81 to clan), their relations to diabetic nephropathy in controlled type 2 diabetic patients. Fourty-eight patients were categorized according to the concentration of urinary microalbunzin per 24h into normoalbuminuric, microalbuminuric and macroalbuminuric groups. Each group comprised 16 patients of both sex. Their age ranged from 42 to 75 years, with a mean value of 57.90.1 years. These patients were compared to 10 healthy subjects, age and sex matched who served as controls. The results of the present work showed that; the mean values of serum TGF-131 in normoalbunzinuric, microalbuminuric and macroalbuminuric groups were significantly elevated compared to the control group (p<0.05). Also, diabetic patients with nephropathy showed that; the mean values of serum TGF-fi 1 in hypertensives were significantly elevated compared to normotensive patients (p<0.05). Furthermore, gender had non-significant effect on serum TGF-/11. Moreover, correlation study showed a significant positive correlation between urinary nzicroalbumin per 24h and serum TGF-131 in microalbuminuric and macroalbuminuric (p<0.05) groups. In addition, systolic and diastolic blood pressure showed signuitant positive correlation with serum TGF-131 in macroalbzuninuric group (p<0.05). The results of this work showed that; the augmented effects of hyperglycemia and the subsequent increase in sem,: TGF-fl 1 could play a prominent role in the pathogenesis of diabetic nephropathy. This may be helpful when using TGF-,81 system as a new therapeutic target for treatment and prevention of diabetic nephropathy in the future.