SERUM OSTEOCALCIN AS A MARKER OF BONE DYNAMICS IN THE ELDERLY
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This study was a trial to evaluate the potential value of serum osteocalcin (B(P) as a marker of bone turnover in elderly osteoporotic male patients and to assess bone dynamics in elderly males via estimation of serum osteocalcin. * Forty-five cases all were males. (15 middle aged normal control cases, 15 elderly non-osteoporotic males and 15 males with senile osteoporosis) comprised the material of this study. * For each case of this study; full history, complete clinical examination laboratory investigations(ineluded blood picture, stool and urine nalysis, blood sugar estimation, renal. and liver profile) for exclusion of any underlying disease, radiologic study (X-ray spine) and estimation of serum calcium, phosphorus, alkaline phosphatase and scrum osteocalcin, all were done. Serum osteocalcin (B(P) was measured by the radioimmunoassay technique. Serum calcium and phosphorus were normal in all subjects of this study. The study revealed that both scrum alkaline phosphatase levels and also, serum osteocalcin levels increased with age, and the increase for these two parameters was higher in the osteoporotic patients. Also, here was a significant correlation between scrum alkaline phosphatase in the elderly groups. We found that serum osteocalcin in the first group case was 3.82±0.8 ng/ml and in the second group was 7.13±1.7 ml while it was 13.40±3.9 ng/ml in the osteoporotic group. We may conclude that serial measurements of serum osteocalcin in elderly individuals may be helpful in study of their bone dynamics and early diagnosis of senile osteoporosis.