OVERPRODUCTION OF TUMOUR NECROSIS FACTOR-a AND INTERLEUKIN -113IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER
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Familial Mediterranean Fever (FMF) is an inherited disorder of unknown etiology characterized by recurrent episodes of serous membrane inflammation that generally last several days and resolve without seguelae. raterteukin-l/3 (1Lrreg) and Tumour Necrosis factor-a (TNF-a) are mediators of inflammatory processes. We hypothesized that LL-I )6 and TNF-a may play a role in pathogenesis and acute attacks of FMF. Thus we tested IL- 4(3 and T1VF-a production from 25 patients with FMF and 15 healthy controls. Fourteen patients were tested during acute attacks and 11 patients were asymptomatic when tested. urto and TNF-a secretion during acute attack was significantly increased whereas IL-1)3 and TNF-a production in asymptomatic patients was high comparable with healthy controls. We concluded that 1L-10 and TNF-a activity in patients with FMF is as+A80 ociated with the intensity of the inflammatory process and play a role in clinical diagnosis and pathogenesis of acute attacks of FMF.