SENSITIVITY AND SPECIFICITY OF MYOGLOBIN IN EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
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This work was carried out on 24 patients suffering from acute chest pain suspicious of acute myocardial infarction ( AMI ) and 10 well matched normal controls . Patients and controls had undergone electro- cardiographic monitoring ( ECG ) , determination of serum creafine phosphokinase ( CPK ) and serum myoglobin by turbidimetric immunoassay . Out of these 24 patients 9 proved to have unstable angina and 15 had AM! . Eleven patients were admitted within 24 hours and 13 within 6 hours from the onset of chest pain. Out of these 13 patients only 9 had AMI . Sensitivity of myoglobin, CPK and ECG in all patients with AM! was 86.8% , 60% and 66.6% respectively. The sensitivity of myoglobin and CPK in AMI patients admitted within 6 hours was 88.8% and 33.33% , respectively . The specificity for myoglobin ,CPK and ECG in all AMI patients was 100% . Therefore serum mygolobin assay by inununoturbidmetric method can be considered as a sensitive and specific test to diagnose AMI in the first few hours and also to identify those patients ithout definite ECG changes.