Publications of Faculty of Medicine:Plasma in rats: Abstract

Plasma in rats
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The present study was conducted on 20 rendered DOCA hypertensive rats. Ten rats served as. a control. The others were treated by long-term administration (4 weeks) of angiotensine converting enzyme inhibitor (ACEI) benazipril, in a dose of 10 mg/kg/day by oral route. The effects of this drug on systolic blood pressure (SBP), heart rate (BR) plasma catetchelamines and electrolytes (Na & were studied. The ACE inhibitor, benazipril, significantly reduced SBP and HR in hypertensive rats. ACEI, benazipril, produced significant decrease in plasma catecholamines. Also there was a significant increase serum IC. It is concluded that ACE', benazipril, produced significant a decrease in SBP & HR through the inhibition of the sympathetic nervous system activity which was manifested by a significant decrease in plasma catecholamines.