The present study was conducted on 20 rendered DOCA hypertensive rats. Ten rats served as.
a control. The others were treated by long-term administration (4 weeks) of angiotensine converting
enzyme inhibitor (ACEI) benazipril, in a dose of 10 mg/kg/day by oral route. The effects of this drug
on systolic blood pressure (SBP), heart rate (BR) plasma catetchelamines and electrolytes (Na &
were studied. The ACE inhibitor, benazipril, significantly reduced SBP and HR in hypertensive rats.
ACEI, benazipril, produced significant decrease in plasma catecholamines. Also there was a
significant increase serum IC.
It is concluded that ACE', benazipril, produced significant a decrease in SBP & HR through
the inhibition of the sympathetic nervous system activity which was manifested by a significant
decrease in plasma catecholamines. |
