A STUDY ON ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)- ASSOCIATED GLOMERULONEPHRITTS
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To evaluate the clinical association of ANCA to glomerulonephritis and probe the possible use of ANCA as a marker for continuing the immunosuppressive therapy in these cases, a study was conducted on 50 histologically proven glomerulonephritis. The cases were divided into two groups. Group I (14 cases) with primary G.N., and group 11 (36 cases) with secondary G.N. Group II was further subdivided into SLE (10 cases),WG. (6 cases), PSGN (10 cases), CSS (5 cases), and PAN (5 cases). The severity of G.N. was determined clinically and using laboratory investigation in the form of the presence of haematuria, casts, proteinuria (> 3g/24hrs), serum creatinine level (51.3 mg/di). The ANCA positivity was determined in all the groups and correlated to the disease entity, severity, and remission & relapse. It was found ANCA positivity correlates well to the severity (p<0.05 with a positive r). It also correlates to relapses as it was found to be positive in 62.5% of cases in relapse, the difference between the remission & relapse was found to be statistically significant (p<0.05). The study could conclude that ANCA may be used as a follow-up tool for patients with G.N and receiving immunosuppressive therapy, as it may affect the drug regimen.