Porphyria Cutanea Tarda and Hepatitis C Virus: Clinical, Histopathological and Virological Study
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Background: Some authors correlated hepatitis C virus infection (HCV) with the development of porphyria cutanea tarda (PCT) considering HCV infection further factor capable of triggering clinical and laboratory manifestations of this disease. Alethods:Vevirtevi4patients with sporadic PCT were investigated. By means of a second generation EL1SA test, serum antibodies against HCV was studied. HCV-RNA was determined by polymerase chain reaction (PCR). Percutaneous ultrasound guided liver biopsy was done to 10 PCT patients. Results: The 76.47% of studied patients were seropositive for HCV antibodies. PCR for HCVRNA was reactive in the 64.70% out of the 17 studied cases. Liver enzymes were significantly increased compared to that of controls. Liver histology revealed minimal, mild, moderate and severe hepatitis in 10%, 30%, 40% and in 20% of the studied cases, respectively. Conclusion: The frequent hepatitis C virus infection in patients with sporadic PCT must be considered as a precipitating factor for the disease and as an aggravating factor for its associated liver damage.