PROMOTION OF PEPTIC ULCER HEALING BY METRONIDAZOLE
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This study was carried out on 60 patients having endoscopically proven chronic active duodenal ulcer. They were divided into three groups: group I, received metronidazole in a dose of 500mg bid for 10 days on two successive months and cimetidine in a dose of 800 mg daily for two months, group II, treated with cimetidine and group III, received antiacids and metronidazole. Two months after drug therapy endoscopic and histopathologic study showed complete healing of peptic ulcer in 90% in group I, 60% in group II and 40% in group III. Therefore, metronidazole has a role in peptic ulcer treatment, its addition to cimetidine augments peptic ulcer healing. Hence it can be used as an adjuvant therapy to promote peptic ulcer healing.