COMBINED SERUM LEVELS OF DCP AND AFP-L3% FOR ASSESSMENT OF PATHOLOGICAL INVASION OF HEPATOCELLULAR CARCINOMA (HCC).
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his study included 26 patients with HCC and 20 controls. Liver biopsies histopathological grading of HCC defined 13 patients with well differentiated, 7 with moderately differentiated and 6 with poorly differentiated HCC. Serum levels of these parameters were significantly higher in patients compared to controls and in patients had poorly compared to patients had well differentiated HCC. Serum of Des-Ycarboxyprothrombin (DCP) and total AFP concentration (AFP-L3%) were significantly higher in patients had poorly compared to those had moderately differentiated HCC, but serum DCP AFP and AFP-L3% levels were not-significantly higher in these respects. Stepwise regression analysis defined serum DCP levels, alone or in combination with other markers, as a significant predictor for the extent of pathological advancement in 3 models of statistical analysis. In conclusion, a panel of DCP and AFP-L3% provided a high noninvasive diagnostic yield for HCC and prediction of its pathological grading especially in compromised or early staged patients.