CHANGES IN PLASMA LIPID CONCENTRATIONS AND SOME COAGULATION FACTOR ACTIVITIES IN INSULIN DEPENDENT DIABETICS WITH AND WITHOUT MICROALBUMINURIA
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This work was carried out to determine the concentration of lipoproteins, apolipoproteins A & B, the clotting factors VII & VIII and antithrombin III in diabetic patients and to investigate the significance of the presence of microalbuminuria in this respect. Fortyfive insulin-dependent diabetic patients- of whom 21 were with and 24 were without microalbuminuria - and 20 healthy controls, were included in the study. The serum total cholesterol, triglycerides, phospholipids, low density liporoteins & apoprotein B were significantly higher while the serum HDL/ LDL and apoprotein Al apoprotein B ratios were significantly lower in diabetic groups. The coagulation factors WI & WII and antithrombin III were significantly higher in diabetic patients than in controls. The abnormalities in the lipid profile & the coagulation parameters were more marked in microalbuminuric than in normoalbuminuric patients. The work shows that insulin- dependent diabetic patients suffer from hyperlipidaemic and hypercoagulability states which are more marked when microalbuminuria is present These changes might be responsible for macro- & microvascular disease with subsequent thromboembolic complications in diabetes. The presence of microalbuminuria should be considered an important warning sign and necessary medical care should start.