Study on the effect of secondary hyperparathyroidism on the bleeding tendency in uremics
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This study was carried out on 25 patients with end stage chronic renal failure maintained on hemodialysis & 15 patients with chronic renal impairment on conservative treatment as well as 10 control subjects. The following investigations were done to each subjects :- Complete blood picture, blood urea, S.creatinine, Serum Ca++, 13++ & ionized calcium, Serum alkaline phosphatase, Serum albumin & total protein, parathormone (PTH) assessment, Platelet aggregation in vitro using ADP and Bleeding time. As regard platelet aggregation the lowest value was in conservative group with highly significant difference between it and hemodialysis group and significant difference between it and control group but no significant difference between control and hemodialysis group. This displayed improvement of platelet aggregation by hemodialysis. There were no significant difference in platelet count between all groups studied. Bleeding time showed the owest value in control group with highly significant difference between it and both conservative & hemodialysis roups,but no significant difference between hemodialysis & conservative groups.PTH showed the lowest values in control group with highly significant difference between it and both hemodialysis & conservative groups but no significant difference between conservative & hemodialysis groups. No correlation was found between platelet aggregation and PTH, or any other haematochemical parameters studied except that platelet aggregation was negatively correlated with bleeding time. No correlation was found between platelets count & PTH.