CORRELATION BETWEEN ANXIETY AND DEPRESSIVE DISORDERS IN PATIENTS WITH FUNCTIONAL DYSPEPSIA: A RANDOMIZED CONTROLLED EGYPTIAN TRIAL
|Full paper||Not Available|
Background and Aim Functional dyspepsia (FDA is the most common type of dyspepsia encountered in primary care and gastroenterology practice. Patients with FD would have a greater prevalence of treatable psychiatric disorders. The aim of this trial was to study the prevalence of psychiatric disorders and somatic symptoms in patients with functional dyspepsia and to compare them with those with duodenal ulcer disease(DU). Patients and Methods: in this prospective randomized controlled study, we selected 100 consecutive FD patients and the same number of endoscopically proven DU patients(as a control group). Patients were subjected to full history taking, complete clinical examination, laboratory investigations, esophagogastroduodenoscopy and psychiatric evaluation through General Health Questionnaire (GHQ), Hospital Anxiety Depression Scale (HADS) and Structured Psychiatric Interview (PSEI0). Results: Patients with FD were significantly younger, more likely to be females, less tendency to smoke, had more frequent dyspeptic symptoms, a longer disease history and lower incidence of H. pylon infection than duodenal ulcer patients. Psychiatric morbidity was significantly higher in FD patients than DU patients (65% compared to 26%). Prevalence of psychiatric disorders was as follow- somatoform disorders 36%, mixed anxiety depressive disorder 21%,generalized anxiety disorder 17%,and depressive episode 4% in FD patients. As regard DU patients; somatoform disorders 8%, mixed anxiety disorder 10% and generalized disorder 8%. Using stepwise logistic regression model, it had been shown that, somatoform autonomic dysfunction and arrdety symptoms of (HADS) were independently associated with functional dyspepsia and the best predictors of diagnosing functional dyspepsia or duodenal ulcer. Conclusion: Psychiatric disorders are strongly associated with functional dyspepsia that warrant psychiatric intervention that may benefit FD patients specially those with chronic symptoms.