SERUM MATRIX METALLOPROTEINASE-9 IN TYPE-2 DIABETES: POSSIBLE ROLE IN DIABETIC NEPHROPATHY
|Full paper||Not Available|
D.N. is one of the major complications of D.M. Several pathogenic mechanisms have been • proposed, such as the presence of glomerular hyperfilteration (and/or hyperperfusion), high activity of protein kinase C, increased nonenzymatic glycosylation of proteins, hypercoagulability, involvement of cytokines, growth factors, heriditary factors and several enzymes that degrade ECM. The four main types are aspartic, cysteine, serine proteinases and MMPs. Of these enzymes. MMPs are thought to play an important role in the pathogenesis of D.N. In an attempt to clan& the role of MMP-9 in DN among type 2 diabetics and its relation to microalbuminurea we select 25 patients with type 2 diabetes with no evidence of DN (no macro or microalbuminurea). (gp I) 40 patients with type 2 DM with evidence of DN (gp II) and 15 apparently healthy age and sex matched subjects as a control group (gp HI). MMP-9 was significantly elevated in the gp II (1085.55±191.18) than in gp 1(517.92±119.99) and gp ifi (192.28±79.32). Microalbuminurea was significantly elevated also in gp 11 (63.03±14.53) than in gp I (17.12±3.93) and gp III (13.23±4.64). Then: wa.s a positive correlation between MMP-9 and disease duration and serum creatinine level amen"; patients in gp 1 Also there was a positive linear relationship between MMP-9 and inicm.ilbuminurca among patients in gp II So we conclude that NIMP-9 was significantly higher among patients with type 2 DM and more significantly elesated among those with D.N. and Itnearly correlated with microalbuminurea. We rccommend that elevated MMP-9 in Type 2 DM may early predict D.N. but further studies were needed to localize the presence of MMP-9 in the diabetic human kidney and to determine the unnary level of this powerful proteinase to clear cut its role in D.N and therapeutic inhibition of this KIMP-9 may improve the outcome of D.N.