THE ENDOGENOUS ANTIOXIDANT ENZYMES IN END-STAGE RENAL DISEASE
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This study was done to evaluate the plasma endogenous antioxidant enzymes activity (glutathione peraxidase, care& rce and superoxide dismutase) in patients with end stage renal disease. Sixty patients were studied. They were divided into two groups: group I (30 patients with chronic renal foilnre on maintenance hemodolysis) and group II (30 patients with different degrees of renal impairment on conservative drug management)). Thirty healthy volunteers with normal kidney function were taken as a control group (group HA For all of them the following was done: full medical history, complete clinical excunination, hemoglobin concentration and hematocrit value, serum urea, creatinirte, uric acid, calcium, phosphorus, fasting and 2 hours postprandial blood sugar, creatinine clearance, and blood levels of superoxide dismutase, glutathione peroxidase and catalase. We found that the blood level of superoirde disrnutase was significantly lower in group I than group 111(P. <0.0001) and it was significantly lower in group II than group HI (P < 0.0001) and there was no significant difference between group I and group II (P < 0.3720). The blood level of glutathione peroxidase was significantly lower in group I than group 1ff (P <0.0001), it was significantly lower in group II than group III (P < 0.0001) and significantly lower in group I than group II (P < 0.0117). The plasma level of catainse was significantly lower in group I than group III (P < 0.001) and it was significantly lower in group H than group III (P < 0.0165) and there was no significant difference between group and group II (P < 0.7002). There was positive correlation between hemo- globin concentration and whole blood superoxide dismutase (r = 0.5767 - Pc 0.0001) and also plasma catalase (r = 0.2348 - P < 0.05). It can be concluded that impaired activity of endogenous antioxidant enzymes occurs early in the course of chronic renal failure and is further exacerbated by hemorlialysis resulting in pemtenant oxidative stress that can be art important mediator contributing to the progression of renal failure and to associated complications such as anemia. Consequently, it may be possible to propose that some antioxidant substances may be usefulfor such patients.