SERUM LIPID PROFILE AND LIPOPROTEIN(a) IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) UNDER DIFFERENT METHODS OF THERAPY
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Eighty subjects (60 patients with chronic renal failure (CRF) under different methods of therapy, in addition to 20 healthy normal control subjects) were included in this study. They were subdivided into the following groups. Group I: included 20 normal healthy subjects as controls. Group II: included 20 patients of CRF under conservative treatment. Group Ill included 20 patients of CRF under haemodialysis (HD). Group IV included 20 patients of CRF under chronic peritoneal dialysis (CPD). For all groups serum lipid profile was done including serum triglycerides, total cholesterol, HDL-C, LDL-C, HDL-C/LDL-C ratio, ApoA, ApoB, ApoA/Apo B ratio and Lipoprotein (a) (Lp(a)). And we get the following results: - There was a significant increase in serum triglycerides in different groups of CRF under different methods of therapy (conservative treatment, haemodialysis and chronic peritoneal dialysis) (P <0.001 for all). - There was a significant increase in total serum cholesterol in patients with CRF under chronic peritoneal dialysis (P < 0.001), but non significant changes in the conservative treatment (P > 0.05) and haemodialysis (P > 0.05) groups. - There was a significant decrease in HDL-C in all the studied groups of CRF under different methods of therapy (P <0.001 for all). - There was a significant increase in LDL-C in CRF patients under CPD (P < 0.001), and non significant changes in its level in the conserevative treatment and HD groups (P > 0.05 for both).